Malaria remains a key target for infectious disease prevention, particularly with resistance to common antimalarial drugs on the uptick.1 However, a broadly effective vaccine for the deadly disease has remained elusive. Now, in a Nature Immunology paper, researchers reported a new mRNA vaccine that induced a tailored immune response in the livers of mice via the activation of liver-specific tissue resident memory T cells (Trm cells), which control early stages of infection and prevent illness.2 With further development, the vaccine could level the playing field in the fight against malaria.
Researchers developed previous malaria vaccines such as RTS,S/AS01 based on a peptide subunit approach; these have only been mildly effective.3 “With RTS,S/AS01, they’re only targeting the window between infection and the transition of those parasites from the skin to the liver. It’s an incredibly short period of time: about two to three hours,” said Lauren Holz, a microbiologist and immunologist from the University of Melbourne and coauthor of the current study.
Holz and her colleagues were inspired by the success of mRNA vaccines during the COVID-19 pandemic. “By using an mRNA-based vaccine, you can encode an entire protein. That means you can expand the epitope range that your Trm cells are targeting,” Holz remarked.
See also “Malaria Parasites Sync with Hosts’ Molecular Rhythms“
The team developed a novel vaccine that contains an mRNA sequence for ribosomal protein L6 (RPL6), a highly conserved Plasmodium protein. This protein is expressed consistently while the parasites are incubating inside the liver; in humans, this duration is about one week.
Liver Trm cells, which the authors found to be responsible for defense against malaria infection in a previous study, are critical for the efficacy of the vaccine.4 With the inclusion of a chemically-modified glycolipid adjuvant, α-galactosylceramide (αGC), the mRNA vaccine causes a small amount of inflammation in the liver that subsequently elicits a robust immune response from the Trm cells. “Originally, we were using [αGC] in cancer research because of the type of immune response it stimulates; it really activates the antigen-presenting cells to make T cell responses. It was really serendipitous that it worked so well in the liver,” said chemist and coauthor Gavin Painter, from the Victoria University of Wellington.
The researchers tested the vaccine along with other available malaria vaccines in mice. Animals treated with the mRNA vaccine had significantly increased liver Trm cell accumulation and were able to resist infection with sporozoites, which drive the early stages of Plasmodium infection. Importantly, the new vaccine was effective even in animals with prior malaria infection, an obstacle that other vaccines failed to overcome.
See also “In Vitro Malaria Sporozoite Production May Lead to Cheaper Vaccines“
Malaria immunology and vaccinology expert Patrick Duffy of the National Institute of Health, who did not contribute to the study, is enthusiastic about the potential of this new vaccine in malaria prevention. “It’s the combination of bringing mRNA vaccines into the malaria field and how this can be tailored to the specific kind of response that is needed for this particular type of vaccine,” Duffy commented. “It is very exciting and clever that they married these two different approaches.”
References
- Plowe CV. Malaria chemoprevention and drug resistance: a review of the literature and policy implications. Malar J. 2022;21(1):104.
- Ganley M, et al. mRNA vaccine against malaria tailored for liver-resident memory T cells. Nat Immunol. 2023;24(9):1487-1498.
- Laurens MB. RTS,S/AS01 vaccine (MosquirixTM): an overview. Hum Vaccin Immunother. 2020;16(3):480-489.
- Fernandez-Ruiz D, et al. Liver-resident memory CD8+ T cells form a front-line defense against malaria liver-stage infection.
https://football-quiz-eg.com/%d9%83%d9%88%d9%84%d8%b1-%d9%84%d9%85-%d8%a3%d8%aa%d8%ae%d9%8a%d9%84-%d9%85%d8%a7-%d8%ad%d8%af%d8%ab-%d9%85%d9%86-%d8%a7%d9%84%d8%ac%d9%85%d8%a7%d9%87%d9%8a%d8%b1/
https://football-player-eg.com/
https://yalla-german.com/category/%d9%85%d8%b3%d8%a7%d8%a8%d9%82%d8%a7%d8%aa/
https://football-today-eg.com/d8aad8b4d983d98ad984-d8a8d8b1d8b4d984d988d986d8a9-d8a3d985d8a7d985-d8b1d98ad8a7d984-d985d8a7d98ad988d8b1d983d8a7-d981d98a-d8a7d984d8af/
Excellent goods from you, man. I have understand your
stuff previous to and you’re just too wonderful.
I really like what you have acquired here, really like what you’re stating and
the way in which you say it. You make it enjoyable and you still care for to keep it sensible.
I can’t wait to read much more from you. This is actually a tremendous web
site.
Thank you, I’ve recently been searching for info approximately
this topic for ages and yours is the best I have came upon so far.
But, what in regards to the conclusion? Are you certain in regards to the source?
It’s remarkable designed for me to have a website, which is valuable in support of my know-how.
thanks admin
The other day, while I was at work, my cousin stole my apple ipad and tested to see if it can survive a thirty
foot drop, just so she can be a youtube sensation. My iPad is now broken and
she has 83 views. I know this is entirely off topic but I had to share it with someone!
Pretty element of content. I simply stumbled upon your
site and in accession capital to say that I get actually enjoyed account your
weblog posts. Any way I’ll be subscribing to your augment or even I fulfillment you get right of entry to consistently
rapidly.
Excellent site you have here but I was wondering if you knew of any user discussion forums that cover the
same topics talked about here? I’d really love to be a part of group where I
can get feed-back from other knowledgeable people that
share the same interest. If you have any recommendations, please let me know.
Kudos!
What’s Taking place i am new to this, I stumbled upon this I’ve discovered It absolutely useful
and it has helped me out loads. I am hoping to contribute & assist different
users like its helped me. Good job.
For latest information you have to visit the web and on world-wide-web I found this web site as a
finest site for most up-to-date updates.
Hi, i think that i saw you visited my web site thus i came
to “return the favor”.I’m attempting to find things to improve
my site!I suppose its ok to use some of your ideas!!
My brother suggested I may like this web site.
He was totally right. This post truly made my day.
You can not imagine just how so much time I had spent for this information!
Thanks!
I every time emailed this website post page to all my contacts, for the reason that
if like to read it then my friends will too.
Hey there! This is my 1st comment here so I just wanted to give a
quick shout out and tell you I truly enjoy reading through your posts.
Can you suggest any other blogs/websites/forums that cover the same topics?
Thank you so much!
I like the helpful info you provide in your articles. I’ll bookmark your
blog and test once more right here frequently.
I’m moderately certain I’ll be told plenty of new stuff proper
right here! Best of luck for the following!
Hello there, just became alert to your blog through Google, and found that
it is really informative. I’m gonna watch out for brussels.
I’ll be grateful if you continue this in future. A lot of people
will be benefited from your writing. Cheers!
This paragraph will assist the internet viewers for building up new blog or even a blog from
start to end.
I loved as much as you’ll receive carried out right here.
The sketch is tasteful, your authored material stylish. nonetheless, you command get
got an shakiness over that you wish be delivering the following.
unwell unquestionably come further formerly again as exactly the same nearly a lot often inside case you shield this hike.
That is very fascinating, You are an overly skilled blogger.
I have joined your rss feed and look forward to looking for more of your excellent post.
Also, I’ve shared your website in my social networks
Hi it’s me, I am also visiting this web page daily, this web page is actually nice
and the users are in fact sharing nice thoughts.
Hi there to every one, the contents existing at this website are truly amazing for people experience, well, keep up the nice work fellows.|
WOW just what I was looking for. Came here by searching for 580bet
Thank you for the good writeup. It in fact was a amusement account
it. Look advanced to far added agreeable from you! However,
how could we communicate?
Its such as you read my thoughts! You seem to understand a
lot about this, such as you wrote the e-book in it or something.
I think that you simply could do with a few percent to power the message home a bit, but other than that, that is fantastic blog.
A great read. I will definitely be back.
Hurrah, that’s what I was seeking for, what a stuff!
present here at this web site, thanks admin of this website.
What’s up, the whole thing is going perfectly here and ofcourse every one is sharing
information, that’s truly fine, keep up writing.
Hello! I realize this is sort of off-topic but I had to ask.
Does running a well-established website like
yours take a massive amount work? I’m completely new to operating a blog
but I do write in my journal daily. I’d like to start a blog so I can easily share my experience and views online.
Please let me know if you have any ideas or tips for
brand new aspiring blog owners. Thankyou!
This information is invaluable. When can I find out more?
Heya i’m for the first time here. I came across this board and I
find It really useful & it helped me out a lot. I hope to give something back and help others like you aided me.
I’m gone to convey my little brother, that he
should also visit this weblog on regular basis to get updated from hottest news
update.
Write more, thats all I have to say. Literally, it seems as though you relied on the video to make your point.
You clearly know what youre talking about, why waste your
intelligence on just posting videos to your site when you could be giving us something informative to read?
Thanks very interesting blog!
Write more, thats all I have to say. Literally, it seems as though you relied on the video to make your point.
You clearly know what youre talking about, why throw away your intelligence on just posting
videos to your weblog when you could be giving us something enlightening
to read?
I got this web page from my friend who told me about this website and now this time I am
visiting this website and reading very informative
posts at this place.
I am not positive the place you’re getting your
information, however great topic. I needs to spend some time studying more or working out more.
Thank you for great info I used to be in search of
this info for my mission.
Hello There. I found your blog using msn. This is
an extremely well written article. I’ll be sure to bookmark it and come back to read more of your useful info.
Thanks for the post. I will certainly comeback.
With havin so much content and articles do
you ever run into any problems of plagorism or copyright infringement?
My site has a lot of unique content I’ve either authored myself or
outsourced but it seems a lot of it is popping it up all over
the web without my agreement. Do you know any techniques to help protect
against content from being ripped off? I’d really appreciate it.
Howdy! This blog post couldn’t be written much better!
Reading through this article reminds me of my previous roommate!
He always kept talking about this. I am going to send this information to
him. Pretty sure he’ll have a great read. I appreciate you for sharing!
A motivating discussion is definitely worth comment. There’s no doubt that that you should publish more on this subject matter, it might not be a taboo matter but usually people don’t talk about
these issues. To the next! Many thanks!!
That is a good tip particularly to those fresh to the blogosphere.
Short but very precise information… Appreciate your sharing this one.
A must read article!
This is my first time visit at here and i am in fact pleassant to read all
at one place.
I was able to find good advice from your blog posts.
Please let me know if you’re looking for a article writer for your weblog.
You have some really good posts and I believe I
would be a good asset. If you ever want to take some of the load
off, I’d absolutely love to write some articles for your blog in exchange for a link back to mine.
Please shoot me an e-mail if interested. Cheers!
Hello there! I just wish to offer you a huge thumbs up for your excellent information you have got here on this post.
I’ll be coming back to your website for more soon.
Howdy are using WordPress for your blog platform? I’m new to the blog world but I’m trying to get started and
create my own. Do you need any html coding knowledge to make your own blog?
Any help would be greatly appreciated!
Excellent way of explaining, and nice post
to get information on the topic of my presentation subject matter,
which i am going to deliver in college.
I’ve been surfing online more than 2 hours today, yet I never found any interesting article like yours. It’s pretty worth enough for me. In my view, if all webmasters and bloggers made good content as you did, the internet will be much more useful than ever before.|
These are genuinely enormous ideas in about blogging.
You have touched some nice factors here. Any way keep up wrinting.
Why users still make use of to read news papers
when in this technological globe all is available on web?
Excellent post. I will be facing a few of these issues as
well..
I don’t think the title of your article matches the content lol. Just kidding, mainly because I had some doubts after reading the article. https://www.binance.info/it/join?ref=S5H7X3LP
I’ve been surfing online more than 4 hours today, yet I never found any interesting article like yours. It’s pretty worth enough for me. In my opinion, if all site owners and bloggers made good content as you did, the internet will be a lot more useful than ever before.|
you are really a just right webmaster. The website loading speed is incredible.
It seems that you are doing any unique trick.
Furthermore, The contents are masterwork. you have performed a wonderful
activity on this topic!
Hello, i think that i saw you visited my site thus i came to
“return the favor”.I am trying to find things to improve my site!I suppose its
ok to use some of your ideas!!
Very nice post. I just stumbled upon your weblog and wanted to mention that I have
really loved browsing your weblog posts. After all I will be subscribing for your
feed and I hope you write again very soon!
I truly love your website.. Excellent colors & theme. Did you make this web site yourself?
Please reply back as I’m trying to create my very own website and would like to know where
you got this from or exactly what the theme is named. Kudos!
Thank you a bunch for sharing this with all folks you actually realize what you’re speaking approximately!
Bookmarked. Kindly additionally consult with my web site =).
We could have a link trade contract between us
Heya this is kinda of off topic but I was wanting to know
if blogs use WYSIWYG editors or if you have to manually code with HTML.
I’m starting a blog soon but have no coding experience so I wanted to get advice from someone with experience.
Any help would be greatly appreciated!
always i used to read smaller articles or reviews
that as well clear their motive, and that is also happening with this piece
of writing which I am reading here.
It’s hard to come by educated people for this subject, however,
you seem like you know what you’re talking about!
Thanks
First of all I would like to say terrific blog! I had a quick question which I’d like to ask if you don’t mind.
I was curious to know how you center yourself and clear
your head prior to writing. I’ve had a hard time clearing my thoughts in getting my ideas out there.
I truly do take pleasure in writing but it just seems like the first 10 to 15 minutes are lost just trying to figure out how to
begin. Any suggestions or hints? Kudos!
Oh my goodness! Awesome article dude! Thank you, However
I am having issues with your RSS. I don’t know why I am unable to subscribe to it.
Is there anybody having the same RSS problems? Anybody who knows
the answer can you kindly respond? Thanx!!
I’m not sure why but this website is loading incredibly slow for me.
Is anyone else having this problem or is it a problem on my end?
I’ll check back later on and see if the problem still exists.
I am extremely inspired along with your writing skills as neatly as with the layout in your weblog.
Is that this a paid topic or did you customize it yourself?
Either way keep up the nice quality writing,
it is rare to peer a great blog like this one nowadays..
Hey there! Do you use Twitter? I’d like to follow you if that would
be okay. I’m definitely enjoying your blog and look forward to new posts.
I got this web page from my buddy who shared with me on the topic
of this web site and at the moment this time I am browsing this web page and reading very informative
articles at this place.
Pretty nice post. I simply stumbled upon your weblog and wanted to mention that I’ve really enjoyed
browsing your blog posts. After all I’ll be subscribing to your feed and I hope you write
again soon!
If you wish for to increase your familiarity simply
keep visiting this web site and be updated with the most recent news posted here.
I have learn several excellent stuff here. Definitely price bookmarking
for revisiting. I wonder how so much attempt you place to create this sort of magnificent
informative site.
hello!,I like your writing so much! proportion we keep in touch more approximately your article on AOL?
I require a specialist in this space to unravel my problem.
May be that’s you! Having a look forward to see you.
Hi there, every time i used to check blog posts here early
in the dawn, for the reason that i like to gain knowledge of more and more.
I am sure this article has touched all the internet visitors, its really really good
paragraph on building up new web site.
Can I just say what a comfort to discover an individual who really knows what they’re talking about on the internet.
You definitely realize how to bring a problem to light and make it important.
More and more people should check this out and understand this side of your story.
I can’t believe you are not more popular since
you definitely have the gift.
Hi! I’ve been reading your website for a while now and finally got the courage to
go ahead and give you a shout out from Houston Texas!
Just wanted to mention keep up the excellent work!
I got this website from my pal who told me on the topic of this web page
and now this time I am browsing this website and
reading very informative articles here.
Good day! I could have sworn I’ve visited this site before but after going
through some of the articles I realized it’s new to me. Regardless, I’m certainly delighted I discovered it and I’ll be bookmarking it and checking back frequently!
Very descriptive post, I enjoyed that a lot. Will there be a part 2?
Very descriptive article, I liked that bit. Will there be a part 2?
Admiring the time and energy you put into your site and
detailed information you present. It’s great to come across a
blog every once in a while that isn’t the same old rehashed material.
Fantastic read! I’ve bookmarked your site and I’m adding your RSS feeds to my Google account.
Hello colleagues, how is all, and what you desire to say
concerning this paragraph, in my view its really awesome designed for me.
Thankfulness to my father who shared with me on the topic of this website,
this web site is in fact amazing.
I’m gone to say to my little brother, that he should also visit this weblog on regular basis to take updated from hottest information.
I know this web site provides quality based articles or reviews and additional stuff, is there any other site which
presents these stuff in quality?
I am not sure where you are getting your info, but good topic.
I needs to spend some time learning more
or understanding more. Thanks for fantastic info I was looking for
this information for my mission.
Heya i am for the first time here. I came across this board and I find It truly useful & it helped me
out much. I hope to provide one thing again and help others like you aided
me.
Whats up very cool blog!! Man .. Excellent .. Wonderful ..
I’ll bookmark your website and take the feeds also?
I’m glad to find so many useful information right here in the post, we want develop more strategies on this regard, thank
you for sharing. . . . . .
Hi there, just wanted to say, I loved this post. It was practical.
Keep on posting!
Hello to every one, it’s truly a pleasant for me to pay a quick visit this web site, it contains valuable Information.
If you wish for to improve your know-how only keep visiting this web site and be
updated with the newest news update posted here.
Hi! This is my 1st comment here so I just wanted to give a
quick shout out and tell you I genuinely enjoy reading through your blog posts.
Can you suggest any other blogs/websites/forums that cover the same subjects?
Thank you!
Every weekend i used to pay a quick visit this web page, because i wish for enjoyment, as this this
web page conations genuinely pleasant funny information too.
I like the valuable information you provide in your articles.
I’ll bookmark your blog and check again here frequently. I am quite sure I will learn plenty of new stuff right here!
Good luck for the next!
I don’t even know how I ended up here, but I thought this post
was great. I don’t know who you are but definitely you are going
to a famous blogger if you are not already 😉 Cheers!
I simply couldn’t leave your site before suggesting that I
extremely loved the usual information an individual
provide on your visitors? Is gonna be back steadily in order to investigate cross-check new posts
I like the helpful information you provide in your articles.
I will bookmark your blog and check again here regularly.
I am quite certain I’ll learn many new stuff right here!
Best of luck for the next!
Everyone loves what you guys are usually up too.
This kind of clever work and reporting! Keep up
the awesome works guys I’ve you guys to my blogroll.
It’s very straightforward to find out any topic
on net as compared to books, as I found this article
at this web site.
Hello there, You’ve done an excellent job. I will definitely digg it and personally recommend to my friends.
I am confident they will be benefited from this
web site.
Hi there friends, its wonderful paragraph on the topic of teachingand fully explained, keep it up all the time.
Hi! Someone in my Facebook group shared this
website with us so I came to give it a look.
I’m definitely enjoying the information. I’m bookmarking
and will be tweeting this to my followers! Terrific blog and terrific design and style.
Woah! I’m really enjoying the template/theme of this
website. It’s simple, yet effective. A lot of times it’s challenging to get that “perfect balance” between usability and visual appeal.
I must say that you’ve done a very good job with this.
Also, the blog loads very fast for me on Safari. Outstanding Blog!
Great delivery. Outstanding arguments. Keep up the amazing work.
Hey there would you mind sharing which blog platform you’re working with?
I’m planning to start my own blog in the near future but I’m having a hard time making a decision between BlogEngine/Wordpress/B2evolution and Drupal.
The reason I ask is because your layout seems different then most blogs and I’m looking
for something completely unique. P.S Sorry for getting off-topic but I had to ask!
I know this web page offers quality depending content and additional data, is there any
other web site which gives these kinds of stuff in quality?
Hi, I do believe this is an excellent website. I stumbledupon it
😉 I may return once again since I bookmarked it.
Money and freedom is the best way to change, may you be rich and continue
to help others.
Hi! I’ve been following your site for a long time
now and finally got the bravery to go ahead and give you a
shout out from New Caney Tx! Just wanted to tell you keep up the
fantastic job!
I am in fact delighted to read this weblog posts which includes plenty of
valuable data, thanks for providing these data.
Hi to every one, the contents existing at this website are actually remarkable for people experience, well,
keep up the good work fellows.
Thanks in support of sharing such a nice idea, article is fastidious, thats why i have read it entirely
I need to to thank you for this great read!! I definitely enjoyed
every little bit of it. I have you book-marked to look at new things you post…
Your style is unique compared to other people I’ve read
stuff from. I appreciate you for posting when you’ve got
the opportunity, Guess I’ll just book mark this blog.
Wonderful beat ! I would like to apprentice even as you amend your
web site, how can i subscribe for a weblog site?
The account helped me a acceptable deal.
I had been tiny bit acquainted of this your broadcast offered bright transparent idea
I’m gone to tell my little brother, that he should also go
to see this webpage on regular basis to get updated from latest
gossip.
Magnificent beat ! I would like to apprentice while you amend your web site, how can i subscribe for a weblog website?
The account aided me a acceptable deal. I have been a little bit familiar of this your broadcast
provided bright clear idea
For hottest information you have to go to see internet and on internet I found this site as a best website for hottest updates.
I every time used to study article in news
papers but now as I am a user of web thus from now I am using net for articles or
reviews, thanks to web.
Very energetic post, I liked that bit. Will there be a part
2?
I do not even know how I ended up here, but I thought this post was great.
I do not know who you are but certainly you’re going to a famous blogger if you are not
already 😉 Cheers!
I was wondering if you ever considered changing the layout of your blog?
Its very well written; I love what youve got to say. But maybe you could a little more in the way of content
so people could connect with it better. Youve got an awful lot of text for only having 1 or two images.
Maybe you could space it out better?
When some one searches for his vital thing, so he/she desires to be available that
in detail, therefore that thing is maintained over
here.
Greetings from Ohio! I’m bored to death at work so I decided to check out your website on my
iphone during lunch break. I really like the information you provide here and can’t wait to take a look when I get home.
I’m surprised at how quick your blog loaded on my cell phone ..
I’m not even using WIFI, just 3G .. Anyways, good site!
Thank you for sharing your info. I truly appreciate your efforts and I will be waiting for your
further write ups thanks once again.
We are a group of volunteers and opening a new scheme in our community.
Your site offered us with valuable info to work on. You
have done a formidable job and our entire community will be grateful
to you.
I have read so many posts concerning the blogger lovers except this paragraph is genuinely a nice piece of writing, keep it up.
Greetings! Quick question that’s completely off topic. Do
you know how to make your site mobile friendly? My website looks weird when viewing from my apple iphone.
I’m trying to find a template or plugin that might be able to fix this issue.
If you have any recommendations, please share. Cheers!
This design is spectacular! You most certainly know how to keep a reader amused.
Between your wit and your videos, I was almost moved to start my own blog (well, almost…HaHa!)
Great job. I really loved what you had to say, and more than that, how you presented it.
Too cool!
Hi there, all is going perfectly here and ofcourse every one is sharing information, that’s really fine,
keep up writing.
After looking at a handful of the articles on your website, I honestly
appreciate your way of blogging. I book marked it to my bookmark webpage list and will be checking back
in the near future. Take a look at my web site too and let me
know what you think.
Can you be more specific about the content of your article? After reading it, I still have some doubts. Hope you can help me.
Hi! Do you know if they make any plugins to assist with SEO?
I’m trying to get my blog to rank for some targeted
keywords but I’m not seeing very good success.
If you know of any please share. Kudos!
Утилизация автомобиля важна для
экологии и экономии.
Feel free to visit my web site – university of bristol blackboard
I am sure this post has touched all the internet users, its really really pleasant
paragraph on building up new webpage.
Thank you for your sharing. I am worried that I lack creative ideas. It is your article that makes me full of hope. Thank you. But, I have a question, can you help me?